Plakophilin-2 is a protein that in humans is encoded by the PKP2 gene. This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. PKP2 is a constituent of the desmosomal plaque in simple epithelia, some stratified epithelia, and some nonepithelial cells. It is also enriched in the karyoplasm of cells of various types, including those lacking desmosomes. PKP proteins participate in linking cadherins to intermediate filaments in the cytoskeleton and this gene product may regulate the signaling activity of beta-catenin. Plakophilin-2 has been shown to interact with Desmoplakin, Plakoglobin and Desmoglein 1.
Formulation
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host
Rabbit
Immunogen Region
An amino acid sequence from the C-terminus of human PKP2 (KKTDFVNSRTAKAYHSLKD) was used as the immunogen for this Plakophilin 2 antibody (100% mouse homology).
Isotype
IgG
Predicted Reactivity
Human, Mouse, Rat
Reactivity
Human, Mouse, Rat
Recombinant
No
Uniprot
Q99959
Format
Antigen affinity purified
Purification
Antigen affinity
Storage
After reconstitution, the Plakophilin 2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.