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Home / Antibodies

PKM Antibody

SKU : BHA10557525

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA794840
Alternative Names	PKM; PK3; OIP3; PK2;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.Christofk, H.R. et al. (2008) Nature 452, 230-3.Mazurek, S. et al. (2005) Semin Cancer Biol 15, 300-8.Dombrauckas, J.D. et al. (2005) Biochemistry 44, 9417-29.Hitosugi, T. et al. (2009) Sci Signal 2, ra73.
Host	Rabbit
Immunogen	Peptide sequence around aa. 36~40(D-S-P-P-I) derived from Human PKM1/2.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival. Christofk, H.R. et al. (2008) Nature 452, 230-3. Mazurek, S. et al. (2005) Semin Cancer Biol 15, 300-8. Dombrauckas, J.D. et al. (2005) Biochemistry 44, 9417-29. Hitosugi, T. et al. (2009) Sci Signal 2, ra73.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total PKM1/2 protein.
Subcellular Location	Cytoplasm, Nucleus

Uniprot	P14618
Database Links	HGNC:9021 OMIM:179050 KEGG:hsa:5315 STRING:9606.ENSP00000320171 UniGene:Hs.534770
Function	Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
Pathway	Glucagon signaling pathway
Protein Families	Pyruvate kinase family
Tissue Specificity	Specifically expressed in proliferating cells, such as embryonic stem cells, embryonic carcinoma cells, as well as cancer cells.

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557525	CSB-PA794840	100ul	$297		Add to Cart

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