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Home / Primary Antibodies

Phospho-VCL (Tyr822) Antibody

SKU : BHA10560134

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA177557
Alternative Names	Vinculin;
Antigen	VCL
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.Subauste MC, et al. (2004) J Cell Biol 165, 371-81 Olsen JV, et al. (2010) Sci Signal 3, ra3 J rgensen C, et al. (2009) Science 326, 1502-9
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of Tyrosine 822 (S-G-Y(p)-R-I) derived from Human Vinculin.
Involvement In Disease	Cardiomyopathy, dilated 1W (CMD1W); Cardiomyopathy, familial hypertrophic 15 (CMH15)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. Subauste MC, et al. (2004) J Cell Biol 165, 371-81 Olsen JV, et al. (2010) Sci Signal 3, ra3 J?rgensen C, et al. (2009) Science 326, 1502-9
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of Vinculin only when phosphorylated at tyrosine 822.
Subcellular Location	Cell membrane, Peripheral membrane protein, Cytoplasmic side, Cell junction, adherens junction, Cell junction, focal adhesion, Cytoplasm, cytoskeleton, Cell membrane, sarcolemma, Peripheral membrane protein, Cytoplasmic side

Uniprot	P18206
Database Links	HGNC:12665 OMIM:193065 KEGG:hsa:7414 STRING:9606.ENSP00000211998 UniGene:Hs.643896
Function	Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
Pathway	Focal adhesion Regulation of actin cytoskeleton Adherens junction Leukocyte transendothelial migration
Protein Families	Vinculin/alpha-catenin family
Tissue Specificity	Metavinculin is muscle-specific.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560134	CSB-PA177557	100ul	$360		Add to Cart

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