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Home / Primary Antibodies

Phospho-Tau Antibody / MAPT (pS396) (RQ5330)

SKU : BHA17110011

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NSJ Bioreagents

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Mfr.No.	RQ5330
Antigen	Phospho-Tau
Clonality	Monoclonal
Description	Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. Pathologies and dementias of the nervous system such as Alzheimer's disease and Parkinson's disease are associated with tau proteins that have become defective and no longer stabilize microtubules properly. Tau is a phosphoprotein with 79 potential Serine (Ser) and Threonine (Thr) phosphorylation sites on the longest tau isoform. Phosphorylation has been reported on approximately 30 of these sites in normal tau proteins. Phosphorylation of tau is regulated by a host of kinases, including PKN, a serine/threonine kinase. When PKN is activated, it phosphorylates tau, resulting in disruption of microtubule organization. Phosphorylation of tau is also developmentally regulated. For example, fetal tau is more highly phosphorylated in the embryonic CNS than adult tau. (Wiki)
Formulation	Antibody in PBS with 0.02% sodium azide and 50% glycerol
Host	Rabbit
Immunogen Region	A synthetic peptide specific to human Tau / MAPT (surrounding pS396) was used as the immunogen for the phospho-Tau antibody.
Isotype	IgG
Predicted Reactivity	Human
Reactivity	Human
Recombinant	No

Uniprot	P10636
Clone No	FCO-13

Format	Purified
Purification	Affinity purified
Storage	Store the phospho-Tau antibody (pS396) at -20°C.

Applications	WB
Dilution	Western blot: 1:10000-1:20000

Product Manual	Data Sheet

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA17110011	RQ5330	100ul	$419		Add to Cart

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