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Home / Primary Antibodies

Phospho-TAL1 (Ser122) Antibody

SKU : BHA10560234

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA117607
Alternative Names	SCL; TAL1; TCL5;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	TAL-1 is a basic helix-loop-helix transcription. Regulates differentiation and survival during hemopoiesis. Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of eryhtroid differentiation. Mutations are associated with T-cell leukemia and melanoma. Binds to the LIM domain containing protein Rhombotin-2. Aplan P.D., Mol. Cell. Biol. 10:6426-6435(1990).Gregory S.G., Nature 441:315-321(2006).Chen Q., J. Exp. Med. 172:1403-1408(1990).
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of Serine 122(Q-L-S(p)-P-P) derived from Human TAL-1.
Involvement In Disease	A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes.
Raised In	Rabbit
Reactivity	Human, Rat
Regulatory	RUO
Relevance	TAL-1 is a basic helix-loop-helix transcription. Regulates differentiation and survival during hemopoiesis. Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of eryhtroid differentiation. Mutations are associated with T-cell leukemia and melanoma. Binds to the LIM domain containing protein Rhombotin-2. Aplan P.D., Mol. Cell. Biol. 10:6426-6435(1990). Gregory S.G., Nature 441:315-321(2006). Chen Q., J. Exp. Med. 172:1403-1408(1990).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of TAL-1 only when phosphorylated at serine 122.
Subcellular Location	Nucleus

Uniprot	P17542
Database Links	HGNC:11556 OMIM:187040 KEGG:hsa:6886 STRING:9606.ENSP00000294339 UniGene:Hs.705618
Function	Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity).
Tissue Specificity	Leukemic stem cell.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560234	CSB-PA117607	100ul	$360		Add to Cart

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