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Home / Primary Antibodies

Phospho-SUFU (Ser342) Antibody

SKU : BHA10560293

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA229368
Alternative Names	SUFUH
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	SUFU encodes a component of the Sonic hedgehog (SHH; MIM 600725)/Patched (PTCH; MIM 601309) signaling pathway. Mutations in genes encoding components of this pathway are deleterious for normal development and are associated with cancer-predisposing syndromes (e.g., HPE3, MIM 142945; BCNS, MIM 109400; and GCPS, MIM 175700)Zimmern P,et al.(2010) Neurourol Urodyn.29(5):715-8.Wang C,et al. (2010) Development. 137(12):2001-9. Rabasseda X.et al.(2010) Drug News Perspect.23(4):273-5.
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of Serine 342 (A-P-S(p)-R-K) derived from Human Sufu.
Involvement In Disease	Medulloblastoma (MDB); Joubert syndrome 32 (JBTS32)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	SUFU encodes a component of the Sonic hedgehog (SHH; MIM 600725)/Patched (PTCH; MIM 601309) signaling pathway. Mutations in genes encoding components of this pathway are deleterious for normal development and are associated with cancer-predisposing syndromes (e.g., HPE3, MIM 142945; BCNS, MIM 109400; and GCPS, MIM 175700) Zimmern P,et al.(2010) Neurourol Urodyn.29(5):715-8. Wang C,et al. (2010) Development. 137(12):2001-9. Rabasseda X.et al.(2010) Drug News Perspect.23(4):273-5.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of Sufu protein only when phosphorylated at serine 342.
Subcellular Location	Cytoplasm, Nucleus

Uniprot	Q9UMX1
Database Links	HGNC:16466 OMIM:155255 KEGG:hsa:51684 STRING:9606.ENSP00000358918 UniGene:Hs.404089
Function	Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes
Pathway	Hedgehog signaling pathway
Protein Families	SUFU family
Tissue Specificity	Ubiquitous in adult tissues. Detected in osteoblasts of the perichondrium in the developing limb of 12-week old embryos. Isoform 1 is detected in fetal brain, lung, kidney and testis. Isoform 2 is detected in fetal testis, and at much lower levels in feta

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560293	CSB-PA229368	100ul	$360		Add to Cart

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