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Home / Primary Antibodies

Phospho-STAT2 (Tyr690) Antibody

SKU : BHA10559980

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA058079
Alternative Names	P113; ISGF-3; STAT113; MGC59816;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) hasbeen shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-a response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. Fu X.Y,et al.Proc. Natl. Acad. Sci. U.S.A. 89:7840-7843(1992)Yan R,et al. Nucleic Acids Res. 23:459-463(1995)Fu X.Y.Cell 70:323-335(1992) Sugiyama T,et al.FEBS Lett. 381:191-194(1996)
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of tyrosine 690 (R-K-Y(p)-L-K)derived from Human Stat2
Involvement In Disease	Immunodeficiency 44 (IMD44)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) hasbeen shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-a response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. Fu X.Y,et al.Proc. Natl. Acad. Sci. U.S.A. 89:7840-7843(1992) Yan R,et al. Nucleic Acids Res. 23:459-463(1995) Fu X.Y.Cell 70:323-335(1992) Sugiyama T,et al.FEBS Lett. 381:191-194(1996)
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of Stat2 only when phosphorylated at Tyrosine 690.
Subcellular Location	Cytoplasm, Nucleus

Uniprot	P52630
Database Links	HGNC:11363 OMIM:600556 KEGG:hsa:6773 STRING:9606.ENSP00000315768 UniGene:Hs.530595
Function	Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state
Pathway	Chemokine signaling pathway Jak-STAT signaling pathway Necroptosis NOD-like receptor signaling pathway Osteoclast differentiation
Protein Families	Transcription factor STAT family

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559980	CSB-PA058079	100ul	$360		Add to Cart

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