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Home / Primary Antibodies

Phospho-SNCA (Ser129) Antibody

SKU : BHA10559936

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA585265
Alternative Names	NACP; SYN; SYUA
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.Takahashi T, et al. J Biol Chem 2003 Oct 24; 278(43): 42225-33Ahn BH, et al. J Biol Chem 2002 Apr 05; 277(14): 12334-42Negro A, et al. FASEB J 2002 Feb; 16(2): 210-2Goldberg, et al. Nat. Cell Biol. 2000; 2, 115-119.
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of serine 129 (M-P-S(p)-E-E) derived from Human a-Synuclein.
Involvement In Disease	Parkinson disease 1, autosomal dominant (PARK1); Parkinson disease 4, autosomal dominant (PARK4); Dementia Lewy body (DLB)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation. Takahashi T, et al. J Biol Chem 2003 Oct 24; 278(43): 42225-33 Ahn BH, et al. J Biol Chem 2002 Apr 05; 277(14): 12334-42 Negro A, et al. FASEB J 2002 Feb; 16(2): 210-2 Goldberg, et al. Nat. Cell Biol. 2000; 2, 115-119.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of a-Synuclein only when phosphorylated at serine 129.
Subcellular Location	Cytoplasm, cytosol, Membrane, Nucleus, Cell junction, synapse, Secreted

Uniprot	P37840
Gene Id	6622
Database Links	HGNC:11138 OMIM:127750 KEGG:hsa:6622 STRING:9606.ENSP00000338345 UniGene:Hs.21374
Function	May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
Protein Families	Synuclein family
Tissue Specificity	Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals.
Weight	14460 MW

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559936	CSB-PA585265	100ul	$360		Add to Cart

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