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Home / Primary Antibodies

Phospho-PLD1 (Thr147) Antibody

SKU : BHA10560237

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA440926
Alternative Names	PLD 1; hPLD1; Choline phosphatase 1;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	Phosphatidylcholine (PC)-specific phospholipases D (PLDs; EC 3.1.4.4) catalyze the hydrolysis of PC to produce phosphatidic acid and choline. A range of agonists acting through G protein-coupled receptors and receptor tyrosine kinases stimulate this hydrolysis. PC-specific PLD activity has been implicated in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis.Hammond S.M., J. Biol. Chem. 272:3860-3868(1997) [PubMed: 9013646].Steed P.M., FASEB J. 12:1309-1317(1998) [PubMed: 9761774].Lopez I., J. Biol. Chem. 273:12846-12852(1998) [PubMed: 9582313].
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of threonine 147(R-H-T(p)-F-R) derived from Human PLD1.
Involvement In Disease	Cardiac valvular defect, developmental (CVDD)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Phosphatidylcholine (PC)-specific phospholipases D (PLDs; EC 3.1.4.4) catalyze the hydrolysis of PC to produce phosphatidic acid and choline. A range of agonists acting through G protein-coupled receptors and receptor tyrosine kinases stimulate this hydrolysis. PC-specific PLD activity has been implicated in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. Hammond S.M., J. Biol. Chem. 272:3860-3868(1997) [PubMed: 9013646]. Steed P.M., FASEB J. 12:1309-1317(1998) [PubMed: 9761774]. Lopez I., J. Biol. Chem. 273:12846-12852(1998) [PubMed: 9582313].
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of PLD1 only when phosphorylated at threonine 147.
Subcellular Location	Cytoplasm, perinuclear region, Endoplasmic reticulum membrane, Lipid-anchor, Cytoplasmic side, Golgi apparatus membrane, Lipid-anchor, Cytoplasmic side, Late endosome membrane, Lipid-anchor, Cytoplasmic side

Uniprot	Q13393
Database Links	HGNC:9067 OMIM:212093 KEGG:hsa:5337 STRING:9606.ENSP00000342793 UniGene:Hs.382865
Function	Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity).
Pathway	cAMP signaling pathway MAPK Erk pathway Ras signaling pathway Fc gamma R-mediated phagocytosis Oxidative Phosphorylation Phospholipase D signaling pathway Sphingolipid signaling pathway Endocytosis Glutamatergic synapse
Protein Families	Phospholipase D family
Tissue Specificity	Expressed abundantly in the pancreas and heart and at high levels in brain, placenta, spleen, uterus and small intestine.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560237	CSB-PA440926	100ul	$360		Add to Cart

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