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Home / Antibodies

Phospho-Pim1 (Tyr309) Antibody

SKU : BHA10560164

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA174999
Alternative Names	PIM-1; Proto-oncogene serine/threonine-protein kinase pim-1; EC 2.7.11.1;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Selten G., Cell 46:603-611(1986).Saris C.J., EMBO J. 10:655-664(1991).Maita H., Eur. J. Biochem. 267:5168-5178(2000).
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of tyrosine 309(A-A-V(p)-W-S) derived from Human Pim-1.
Involvement In Disease	Frequently activated by provirus insertion in murine leukemia virus-induced T-cell lymphomas.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Selten G., Cell 46:603-611(1986). Saris C.J., EMBO J. 10:655-664(1991). Maita H., Eur. J. Biochem. 267:5168-5178(2000).
Species	Mus Musculus (Mouse)
Specificity	The antibody detects endogenous levels of Pim-1 only when phosphorylated at tyrosine 309.
Subcellular Location	Cytoplasm, Nucleus, Cell membrane

Uniprot	P06803
Database Links	STRING:10090.ENSMUSP00000024811 UniGene:Mm.405293
Function	Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through
Pathway	Jak-STAT signaling pathway AGE-RAGE signaling pathway in diabetic complications
Protein Families	Protein kinase superfamily, CAMK Ser/Thr protein kinase family, PIM subfamily

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560164	CSB-PA174999	100ul	$360		Add to Cart

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