Phospho-PDCD4 (Ser457) Antibody

Mfr.No.	AF3465
Alternative Names	Death up-regulated gene protein ; Dug ; H731 ; Ma3 ; MGC33046 ; MGC33047 ; Neoplastic transformation inhibitor ; Neoplastic transformation inhibitor protein ; Nuclear antigen H731 ; Nuclear antigen H731 like ; Nuclear antigen H731 like protein ; Nuclear antigen H731-like ; PDCD 4 ; Pdcd4 ; PDCD4_HUMAN ; Programmed cell death 4 ; programmed cell death 4 (neoplastic transformation inhibitor) ; Programmed cell death protein 4 ; Protein 197/15a ; Protein MA-3 ; Tis ; Topoisomerase-inhibitor suppressed protein ;
Antigen	Phospho-PDCD4 (Ser457)
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	This gene encodes a protein localized to the nucleus in proliferating cells. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two transcripts encoding different isoforms have been identified.
Immunogen	A synthesized peptide derived from human PDCD4 around the phosphorylation site of Serine 457.
Molecular Weight	Observed Mol.Wt.: 51kDa. Predicted Mol.Wt.: 52kDa.
Reactivity	Human, Mouse, Rat
Specificity	Phospho-PDCD4 (Ser457) Antibody detects endogenous levels of PDCD4 only when phosphorylated at Serine 457.
Subcellular Location	Nucleus. Cytoplasm. Shuttles between the nucleus and cytoplasm. Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457. Exported from the nucleus in the absence of serum.

Uniprot

Q53EL6

Gene Id

27250

Sequence

10	20	30	40	50
MDVENEQILN	VNPADPDNLS	DSLFSGDEEN	AGTEEIKNEI	NGNWISASSI
60	70	80	90	100
NEARINAKAK	RRLRKNSSRD	SGRGDSVSDS	GSDALRSGLT	VPTSPKGRLL
110	120	130	140	150
DRRSRSGKGR	GLPKKGGAGG	KGVWGTPGQV	YDVEEVDVKD	PNYDDDQENC
160	170	180	190	200
VYETVVLPLD	ERAFEKTLTP	IIQEYFEHGD	TNEVAEMLRD	LNLGEMKSGV
210	220	230	240	250
PVLAVSLALE	GKASHREMTS	KLLSDLCGTV	MSTTDVEKSF	DKLLKDLPEL
260	270	280	290	300
ALDTPRAPQL	VGQFIARAVG	DGILCNTYID	SYKGTVDCVQ	ARAALDKATV
310	320	330	340	350
LLSMSKGGKR	KDSVWGSGGG	QQSVNHLVKE	IDMLLKEYLL	SGDISEAEHC
360	370	380	390	400
LKELEVPHFH	HELVYEAIIM	VLESTGESTF	KMILDLLKSL	WKSSTITVDQ
410	420	430	440	450
MKRGYERIYN	EIPDINLDVP	HSYSVLERFV	EECFQAGIIS	KQLRDLCPSR
460
GRKRFVSEGD	GGRLKPESY

Concentration	1mg/ml
Format	Liquid
Purification	The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Storage Condition	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.