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Home / Antibodies

Phospho-PAK7/PAK6 (Ser602/Ser560) Antibody

SKU : BHA10560233

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA285604
Alternative Names	PAK5; PAK 6; kinase PAK6;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	This gene encodes a protein that shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. The protein encoded by this gene was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. Yang F., J. Biol. Chem. 276:15345-15353(2001).Wagner T., Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.Sjoeblom T., Science 314:268-274(2006).
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of Serine 602/560(R-K-S(p)-L-V) derived from Human PAK5/6.
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	This gene encodes a protein that shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. The protein encoded by this gene was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. Yang F., J. Biol. Chem. 276:15345-15353(2001). Wagner T., Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases. Sjoeblom T., Science 314:268-274(2006).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of PAK5/6 only when phosphorylated at serine 602/560.
Subcellular Location	Mitochondrion, Cytoplasm, Nucleus

Uniprot	Q9P286
Database Links	HGNC:15916 OMIM:608038 KEGG:hsa:57144 STRING:9606.ENSP00000322957 UniGene:Hs.32539
Function	Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.
Pathway	ErbB signaling pathway Focal adhesion Regulation of actin cytoskeleton Ras signaling pathway T cell receptor signaling pathway
Protein Families	Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
Tissue Specificity	Predominantly expressed in brain.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560233	CSB-PA285604	100ul	$360		Add to Cart

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