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Home / Primary Antibodies

Phospho-MUSK (Tyr755) Antibody

SKU : BHA10560264

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA204567
Alternative Names	MUSK; Muscle; skeletal;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. Valenzuela D.M., Neuron 15:573-584(1995).Humphray S.J., Nature 429:369-374(2004).Bergamin E., Mol. Cell 39:100-109(2010).
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of tyrosine 755(A-D-Y(p)-Y-K) derived from Human MuSK .
Involvement In Disease	Myasthenic syndrome, congenital, 9, associated with acetylcholine receptor deficiency (CMS9); Fetal akinesia deformation sequence (FADS)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. Valenzuela D.M., Neuron 15:573-584(1995). Humphray S.J., Nature 429:369-374(2004). Bergamin E., Mol. Cell 39:100-109(2010).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of MuSK only when phosphorylated at tyrosine 755.
Subcellular Location	Cell junction, synapse, postsynaptic cell membrane, Single-pass type I membrane protein

Uniprot	O15146
Database Links	HGNC:7525 OMIM:208150 KEGG:hsa:4593 STRING:9606.ENSP00000363571 UniGene:Hs.521653
Function	Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle
Protein Families	Protein kinase superfamily, Tyr protein kinase family

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560264	CSB-PA204567	100ul	$360		Add to Cart

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