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Home / Primary Antibodies

phospho-MLKL (S358) Mouse Monoclonal Antibody (6F8)

SKU : BHA13715378

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Abbkine Scientific Co., Ltd.

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Mfr.No.	ABM40324
Alternative Names	MLKL
Background	MLKL (mixed lineage kinase domain like) belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF) -induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of MLKL inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for MLKL.
Clonality	Monoclonal
Conjugate	The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen
Description	Mouse Anti-phospho-MLKL (S358) Mouse Monoclonal Antibody (6F8)
Formulation	The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen, Liquid solution
Host	Mouse
Immunogen	Synthetic Peptide of phospho-MLKL (S358)
Immunogen Region	Synthetic Peptide of phospho-MLKL (S358)
Isotype	Mouse IgG1
Others	phospho-MLKL (S358) protein detects endogenous levels of MLKL. Observed Band (KD): 54
Precautions	The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Reactivity	Human
Tag	MLKL
Note	Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC-P (1:100-1:200).

Accession Number	Q8NB16
Gene Id	197259, 197259

Concentration	1 mg/ml, 1 mg/ml
Purification	The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen, The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen
Storage Buffer	PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage Instructions	Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Applications	IHC-P, IF

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA13715378	ABM40324	30 uL	$109		Add to Cart
BHA13715378	ABM40324	100 uL	$239		Add to Cart
BHA13715378	ABM40324	200 uL	$379		Add to Cart

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