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Home / Primary Antibodies

Phospho-KCNJ11 (Thr224) Antibody

SKU : BHA10560491

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA209100
Alternative Names	ATP-sensitive inward rectifier potassium channel 11; IKATP; IRK11; Inward rectifier K channel Kir6.2; KCNJ11; Potassium channel; inwardly rectifying; subfamily J; member 11
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium By similarity. Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of threonine 224 (K-T-TP-S-P) derived from Human Kir6.2.
Involvement In Disease	Familial hyperinsulinemic hypoglycemia 2 (HHF2); Diabetes mellitus, permanent neonatal (PNDM); Transient neonatal diabetes mellitus 3 (TNDM3); Maturity-onset diabetes of the young 13 (MODY13)
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium By similarity. Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of Kir6.2 only when phosphorylated at threonine 224.
Subcellular Location	Membrane, Multi-pass membrane protein

Uniprot	Q14654
Gene Id	3767
Database Links	HGNC:6257 OMIM:600937 KEGG:hsa:3767 STRING:9606.ENSP00000345708 UniGene:Hs.248141
Function	This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.
Protein Families	Inward rectifier-type potassium channel (TC 1.A.2.1) family, KCNJ11 subfamily
Weight	43,541 Da

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IF

Description

ELISA ; WB ; IF, WB ; ELISA ; IF

Dilution

WB	1:500-1:1000
IF	1:100-1:200

Tested Application

ELISA,WB,IF;WB:1:500-1:1000,IF:1:100-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560491	CSB-PA209100	100ul	$360		Add to Cart

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