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Home / Primary Antibodies

Phospho-IRS1 (Ser312) Antibody

SKU : BHA10559971

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA174165
Alternative Names	HIRS-1; IRS1; Insulin receptor substrate 1
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit Tzatsos A, et al. (2006) Mol Cell Biol; 26(1): 63-76Ozes ON, et al. (2001) Proc Natl Acad Sci U S A; 98(8): 4640-4645Szanto I, et al. (2000) Proc Natl Acad Sci U S A; 97(5): 2355-2360Ozes ON, et al. (2001) Proc Natl Acad Sci U S A; 98(8): 4640-4645
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of serine 312 (A-T-S(p)-P-A) derived from Human IRS-1.
Involvement In Disease	Diabetes mellitus, non-insulin-dependent (NIDDM)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit Tzatsos A, et al. (2006) Mol Cell Biol; 26(1): 63-76 Ozes ON, et al. (2001) Proc Natl Acad Sci U S A; 98(8): 4640-4645 Szanto I, et al. (2000) Proc Natl Acad Sci U S A; 97(5): 2355-2360 Ozes ON, et al. (2001) Proc Natl Acad Sci U S A; 98(8): 4640-4645
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of IRS-1 only when phosphorylated at serine 312.

Uniprot	P35568
Database Links	HGNC:6125 OMIM:125853 KEGG:hsa:3667 STRING:9606.ENSP00000304895 UniGene:Hs.471508
Function	May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).
Pathway	mTOR signaling pathway PI3K-Akt signaling pathway Autophagy Adipocytokine signaling pathway AMPK signaling cGMP-PKG signaling pathway FoxO signaling pathway Insulin signaling pathway Neurotrophin signaling pathway

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559971	CSB-PA174165	100ul	$360		Add to Cart

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