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Home / Antibodies

Phospho-INSR (Tyr1355) Antibody

SKU : BHA10560103

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA203919
Alternative Names	CD220 antigen; IR; insulin receptor; kinase InsR;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2. Tennagels N, et al. (2001) Biochem Biophys Res Commun 282, 387-93 Tennagels N, Bergschneider E, Al-Hasani H, Klein HW (2000) FEBS Lett 479, 67-71 Noelle V, Tennagels N, Klein HW (2000) Biochemistry 39, 7170-7
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of tyrosine 1355 (R-S-Y(p)-E-E) derived from Human IR.
Involvement In Disease	Rabson-Mendenhall syndrome (RMS); Leprechaunism (LEPRCH); Diabetes mellitus, non-insulin-dependent (NIDDM); Familial hyperinsulinemic hypoglycemia 5 (HHF5); Insulin-resistant diabetes mellitus with acanthosis nigricans type A (IRAN type A)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2. Tennagels N, et al. (2001) Biochem Biophys Res Commun 282, 387-93 Tennagels N, Bergschneider E, Al-Hasani H, Klein HW (2000) FEBS Lett 479, 67-71 Noelle V, Tennagels N, Klein HW (2000) Biochemistry 39, 7170-7
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of IR only when phosphorylated at tyrosine 1355.
Subcellular Location	Cell membrane, Single-pass type I membrane protein

Uniprot	P06213
Database Links	HGNC:6091 OMIM:125853 KEGG:hsa:3643 STRING:9606.ENSP00000303830 UniGene:Hs.465744
Function	Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways
Pathway	HIF-1 signaling pathway MAPK signaling pathway mTOR signaling pathway PI3K-Akt signaling pathway Adherens junction Ras signaling pathway AMPK signaling cGMP-PKG signaling pathway FoxO signaling pathway Insulin signaling pathway Phospholipase D signaling pathway Rap1 signaling pathway
Protein Families	Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily
Tissue Specificity	Isoform Long and isoform Short are predominantly expressed in tissue targets of insulin metabolic effects: liver, adipose tissue and skeletal muscle but are also expressed in the peripheral nerve, kidney, pulmonary alveoli, pancreatic acini, placenta vasc

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560103	CSB-PA203919	100ul	$360		Add to Cart

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