In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.de Backer M.D., Biochem. Biophys. Res. Commun. 197:1601-1608(1993).Fukui K., Biochem. Biophys. Res. Commun. 201:894-901(1994).Sjoeblom T., Science 314:268-274(2006)
Host
Rabbit
Immunogen
Peptide sequence around phosphorylation site of Serine 398(S-H-S(p)-R-Q) derived from Human Histamine H1 Receptor .
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
de Backer M.D., Biochem. Biophys. Res. Commun. 197:1601-1608(1993). Fukui K., Biochem. Biophys. Res. Commun. 201:894-901(1994). Sjoeblom T., Science 314:268-274(2006)
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of Histamine H1 Receptor only when phosphorylated at serine 398.
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
Pathway
Calcium signaling pathway
Protein Families
G-protein coupled receptor 1 family
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.