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Home / Antibodies

Phospho-HNF4A (Ser304) Antibody

SKU : BHA10559978

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA443636
Alternative Names	HNF4; TCF; MODY; HNF4A;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes,including hepatocyte nuclear factor 1 a, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants. Kritis A.A,et al.Gene 173:275-280(1996)Drewes T,et al.Mol. Cell. Biol. 16:925-931(1996) Yamagata K,et al.Nature 384:458-460(1996)Tanaka T,et al.Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of serine 304 (L-R-S(p)-Q-V)derived from Human HNF4a.
Involvement In Disease	Maturity-onset diabetes of the young 1 (MODY1); Diabetes mellitus, non-insulin-dependent (NIDDM); Fanconi renotubular syndrome 4 with maturity-onset diabetes of the young (FRTS4)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes,including hepatocyte nuclear factor 1 a, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants. Kritis A.A,et al.Gene 173:275-280(1996) Drewes T,et al.Mol. Cell. Biol. 16:925-931(1996) Yamagata K,et al.Nature 384:458-460(1996) Tanaka T,et al.Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of HNF4a only when phosphorylated at serine 304.
Subcellular Location	Nucleus

Uniprot	P41235
Database Links	HGNC:5024 OMIM:125850 KEGG:hsa:3172 STRING:9606.ENSP00000312987 UniGene:Hs.116462
Function	Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1-antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1-alpha. May be essential for development of the liver, kidney and intestine.
Pathway	AMPK signaling
Protein Families	Nuclear hormone receptor family, NR2 subfamily

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559978	CSB-PA443636	100ul	$360		Add to Cart

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