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Home / Primary Antibodies

Phospho-GRIN2B (Ser1303) Antibody

SKU : BHA10560239

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA071137
Alternative Names	GRIN2B; NMDE2; NME2; NR2B; NR3
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain.Adams S.L., Biochim. Biophys. Acta 1260:105-108(1995).Hess S.D., J. Pharmacol. Exp. Ther. 278:808-816(1996).Mandich P., Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of Serine 1303(Q-H-S(p)-Y-D) derived from Human GRIN2B.
Involvement In Disease	Mental retardation, autosomal dominant 6, with or without seizures (MRD6); Epileptic encephalopathy, early infantile, 27 (EIEE27)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. Adams S.L., Biochim. Biophys. Acta 1260:105-108(1995). Hess S.D., J. Pharmacol. Exp. Ther. 278:808-816(1996). Mandich P., Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of GRIN2B only when phosphorylated at serine 1303.
Subcellular Location	Cell membrane, Multi-pass membrane protein, Cell junction, synapse, postsynaptic cell membrane, Multi-pass membrane protein

Uniprot	Q13224
Database Links	HGNC:4586 OMIM:138252 KEGG:hsa:2904 STRING:9606.ENSP00000279593 UniGene:Hs.504844
Function	Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+)
Pathway	cAMP signaling pathway Ras signaling pathway Rap1 signaling pathway Glutamatergic synapse
Protein Families	Glutamate-gated ion channel (TC 1.A.10.1) family, NR2B/GRIN2B subfamily
Tissue Specificity	Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560239	CSB-PA071137	100ul	$360		Add to Cart

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