Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3'. Acts as a transcriptional activator of ANF in cooperation with NKX2-5 By similarity. Promotes cardiac myocyte enlargement.
Host
Rabbit
Immunogen
Peptide sequence around phosphorylation site of Serine 262(R-L-S(p)-A-S) derived from Human GATA4.
Involvement In Disease
Atrial septal defect 2 (ASD2); Ventricular septal defect 1 (VSD1); Tetralogy of Fallot (TOF); Atrioventricular septal defect 4 (AVSD4); Testicular anomalies with or without congenital heart disease (TACHD)
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3'. Acts as a transcriptional activator of ANF in cooperation with NKX2-5 By similarity. Promotes cardiac myocyte enlargement.
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous level of GATA4 only when phosphorylated at Serine 262.
Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development and function
Pathway
Cellular senescence cGMP-PKG signaling pathway
Buffer
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.