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Home / Antibodies

Phospho-GAP43 (Ser41) Antibody

SKU : BHA10559955

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA011221
Alternative Names	B-50; BASP2; NEUM; PP46; axonal membrane protein GAP-43
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	GAP43 encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.Rachael L. Neve, et,al. (1998) J. Neurosci; 18: 7757. Yiping Shen, et,al. (2002) J. Neurosci; 22: 239.Chantal Gamby, et,al. (1996) J. Biol. Chem; 271: 26698.
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of Ser41 (Q-A-S(p)-F-R) derived from Human GAP43.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	GAP43 encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Rachael L. Neve, et,al. (1998) J. Neurosci; 18: 7757. Yiping Shen, et,al. (2002) J. Neurosci; 22: 239. Chantal Gamby, et,al. (1996) J. Biol. Chem; 271: 26698.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of GAP43 only when phosphorylated at Ser41.
Subcellular Location	Cell membrane, Peripheral membrane protein, Cytoplasmic side, Cell projection, growth cone membrane, Peripheral membrane protein, Cytoplasmic side, Cell junction, synapse, Cell projection, filopodium membrane, Peripheral membrane protein

Uniprot	P17677
Database Links	HGNC:4140 OMIM:162060 KEGG:hsa:2596 STRING:9606.ENSP00000377372 UniGene:Hs.134974
Function	This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
Protein Families	Neuromodulin family

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, IF

Description

ELISA ; IF, IF ; ELISA

Dilution

IF	1:100-1:200

Tested Application

ELISA,IF;IF:1:100-1:200

Datasheet
ELISA Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559955	CSB-PA011221	100ul	$360		Add to Cart

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