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Home / Primary Antibodies

Phospho-FCGR2B (Tyr292) Antibody

SKU : BHA10560163

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA785845
Alternative Names	CD32; FCG2; FCG2B,; LY-17; CDW32
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.Stuart S.G., EMBO J. 8:3657-3666(1989).Brooks D.G., J. Exp. Med. 170:1369-1385(1989).Engelhardt W., Eur. J. Immunol. 20:1367-1377(1990).
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of tyrosine 292 (I-T-Y(p)-S-L) derived from Human CD32.
Involvement In Disease	Systemic lupus erythematosus (SLE)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis. Stuart S.G., EMBO J. 8:3657-3666(1989). Brooks D.G., J. Exp. Med. 170:1369-1385(1989). Engelhardt W., Eur. J. Immunol. 20:1367-1377(1990).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of CD32 only when phosphorylated at tyrosine 292.
Subcellular Location	Cell membrane, Single-pass type I membrane protein

Uniprot	P31994
Database Links	HGNC:3618 OMIM:152700 KEGG:hsa:2213 STRING:9606.ENSP00000351497 UniGene:Hs.654395
Function	Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.
Pathway	B cell receptor signaling pathway Fc gamma R-mediated phagocytosis Osteoclast differentiation
Tissue Specificity	Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560163	CSB-PA785845	100ul	$360		Add to Cart

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