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Home / Primary Antibodies

Phospho-EPB41 (Tyr660/418) Antibody

SKU : BHA10560227

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA242308
Alternative Names	E41P; EPB4.1; band 4.1; P4.1;
Antigen	EPB41
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	Elliptocytosis is a hematologic disorder characterized by elliptically shaped erythrocytes and a variable degree of hemolytic anemia. Inherited as an autosomal dominant, elliptocytosis results from mutation in any one of several genes encoding proteins of the red cell membrane skeleton. The form discussed here is the one found in the 1950s to be linked to Rh blood group and more recently shown to be caused by a defect in protein 4.1. 'Rh-unlinked' forms of elliptocytosis are caused by mutation in the alpha-spectrin gene, the beta-spectrin gene, or the band 3 gene.Conboy J.G., Proc. Natl. Acad. Sci. U.S.A. 83:9512-9516(1986).Tang T.K., Adv. Exp. Med. Biol. 241:81-95(1988).Tang T.K., Proc. Natl. Acad. Sci. U.S.A. 85:3713-3717(1988).
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of tyrosine 660/418 (N-I-Y(p)-I-R)derived from Human EPB41.
Involvement In Disease	Elliptocytosis 1 (EL1)
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Elliptocytosis is a hematologic disorder characterized by elliptically shaped erythrocytes and a variable degree of hemolytic anemia. Inherited as an autosomal dominant, elliptocytosis results from mutation in any one of several genes encoding proteins of the red cell membrane skeleton. The form discussed here is the one found in the 1950s to be linked to Rh blood group and more recently shown to be caused by a defect in protein 4.1. 'Rh-unlinked' forms of elliptocytosis are caused by mutation in the alpha-spectrin gene, the beta-spectrin gene, or the band 3 gene. Conboy J.G., Proc. Natl. Acad. Sci. U.S.A. 83:9512-9516(1986). Tang T.K., Adv. Exp. Med. Biol. 241:81-95(1988). Tang T.K., Proc. Natl. Acad. Sci. U.S.A. 85:3713-3717(1988).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of EPB41 only when phosphorylated at tyrosine 660/418.
Subcellular Location	Cytoplasm, cytoskeleton, Cytoplasm, cell cortex, Nucleus

Uniprot	P11171
Database Links	HGNC:3377 OMIM:130500 KEGG:hsa:2035 STRING:9606.ENSP00000345259 UniGene:Hs.175437
Function	Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560227	CSB-PA242308	100ul	$360		Add to Cart

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