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Home / Antibodies

Phospho-EFNB2 (Tyr330) Antibody

SKU : BHA10559975

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA216331
Alternative Names	HTKL; EPLG5; Htk-L; LERK5; MGC126226
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	Adducins are a family of cytoskeleton proteins encoded by three genes (a, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. a- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. a- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. Chrencik JE,et al.( 2006) J Biol Chem;281(38):28185-28192.Kertesz N, et al. (2006) Blood; 107(6):2330-2338.Noren NK, et al. (2004) Proc Natl Acad Sci USA; 101(15):5583-5588.
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of tyrosine 330 (N-I-Y(p)-Y-K) derived from Human Ephrin-B2
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Adducins are a family of cytoskeleton proteins encoded by three genes (a, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. a- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. a- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. Chrencik JE,et al.( 2006) J Biol Chem;281(38):28185-28192. Kertesz N, et al. (2006) Blood; 107(6):2330-2338. Noren NK, et al. (2004) Proc Natl Acad Sci USA; 101(15):5583-5588.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of Ephrin-B2 only when phosphorylated at tyrosine 330.
Subcellular Location	Membrane, Single-pass type I membrane protein

Uniprot	P52799
Database Links	HGNC:3227 OMIM:600527 KEGG:hsa:1948 STRING:9606.ENSP00000245323 UniGene:Hs.149239
Function	Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.
Protein Families	Ephrin family
Tissue Specificity	Lung and kidney.

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559975	CSB-PA216331	100ul	$360		Add to Cart

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