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Home / Antibodies

Phospho-EFNB2 (Tyr316) Antibody

SKU : BHA10559974

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA166153
Alternative Names	HTKL; EPLG5; Htk-L; LERK5;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene.Chrencik JE,et al.( 2006) J Biol Chem;281(38):28185-28192.Kertesz N, et al.( 2006) Blood;107(6):2330-2338.Noren NK, et al.( 2004) Proc Natl Acad Sci USA;101(15):5583-5588
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of tyrosine 316 (P-V-Y(p)-I-V) derived from Human Ephrin-B2
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. Chrencik JE,et al.( 2006) J Biol Chem;281(38):28185-28192. Kertesz N, et al.( 2006) Blood;107(6):2330-2338. Noren NK, et al.( 2004) Proc Natl Acad Sci USA;101(15):5583-5588
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of Ephrin-B2 only when phosphorylated at tyrosine 316.
Subcellular Location	Membrane, Single-pass type I membrane protein

Uniprot	P52799
Database Links	HGNC:3227 OMIM:600527 KEGG:hsa:1948 STRING:9606.ENSP00000245323 UniGene:Hs.149239
Function	Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.
Protein Families	Ephrin family
Tissue Specificity	Lung and kidney.

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559974	CSB-PA166153	100ul	$360		Add to Cart

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