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Home / Primary Antibodies

Phospho-DDIT3 (Ser30) Antibody

SKU : BHA10560137

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA799326
Alternative Names	C/EBP-homologous protein; DDIT3; GADD153; DNA-damage inducible transcript 3;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Ubeda M, Habener JF (2003) J Biol Chem 278, 40514-20
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of serine30(V-L-S(p)-S-D) derived from Human CHOP .
Involvement In Disease	Myxoid liposarcoma (MXLIPO)
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Ubeda M, Habener JF (2003) J Biol Chem 278, 40514-20
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of CHOP only when phosphorylated at serine 30.
Subcellular Location	Cytoplasm, Nucleus

Uniprot	P35638
Database Links	HGNC:2726 OMIM:126337 KEGG:hsa:1649 STRING:9606.ENSP00000447803 UniGene:Hs.505777
Function	Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription
Pathway	MAPK signaling pathway Apoptosis Protein processing in endoplasmic reticulum ER Stress pathway
Protein Families	BZIP family

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560137	CSB-PA799326	100ul	$360		Add to Cart

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