JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Antibodies

Phospho-CTTN (Tyr466) Antibody

SKU : BHA10560393

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

CUSABIO TECHONOLOGY LLC

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	CSB-PA944105
Alternative Names	Amplaxin; CTTN; EMS1; SRC8;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	Cortactin is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Two splice variants that encode different isoforms have been identified for this gene. Luo C, et al. (2006) J Biol Chem 281(40):30081-30093 Head JA, et al. (2003) Mol Biol Cell ;14(8):3216-3229 Li Y, et al. (2000) J Biol Chem 275(47): 37187-37193 Kinley AW, et al. (2003) Curr Biol 13(5): 384-393
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of tyrosine 466 (P-V-Y(p)-E-T) derived from Human CORTACTIN.
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Cortactin is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Two splice variants that encode different isoforms have been identified for this gene. Luo C, et al. (2006) J Biol Chem ; 281(40):30081-30093 Head JA, et al. (2003) Mol Biol Cell ;14(8):3216-3229 Li Y, et al. (2000) J Biol Chem ; 275(47): 37187-37193 Kinley AW, et al. (2003) Curr Biol ; 13(5): 384-393
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of Cortactin only when phosphorylated at tyrosine 466.
Subcellular Location	Cytoplasm, cytoskeleton, Cell projection, lamellipodium, Cell projection, ruffle, Cell projection, dendrite, Cell projection, Cell membrane, Peripheral membrane protein, Cytoplasmic side, Cell projection, podosome, Cell junction, Cell junction, focal adhesion, Membrane, clathrin-coated pit, Cell projection, dendritic spine, Cytoplasm, cell cortex

Uniprot	Q14247
Database Links	HGNC:3338 OMIM:164765 KEGG:hsa:2017 UniGene:Hs.596164
Function	Contributes to the organization of the actin cytoskeleton and cell shape

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

Have you used this product?

Rate it now..!!

Login to Review

SKU	Supplier No.	Size	Your price	Quantity
BHA10560393	CSB-PA944105	100ul	$360		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2024 Biohippo. All rights reserved.