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Home / Antibodies

Phospho-CLDN7 (Tyr210) Antibody

SKU : BHA10560225

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA729723
Alternative Names	CEPTRL2; claudin 7; CLD7; CPETRL2; CLDN7
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	Claudins, such as CLDN7, are involved in the formation of tight junctions between epithelial cells. Tight junctions restrict lateral diffusion of lipids and membrane proteins, and thereby physically define the border between the apical and basolateral compartments of epithelial cells.Keen T.J.; Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.Kalnine N., Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.The MGC Project Team; Genome Res. 14:2121-2127(2004).
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of tyrosine 210 (S-K-E-Y(p)-V) derived from Human Claudin 7.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Claudins, such as CLDN7, are involved in the formation of tight junctions between epithelial cells. Tight junctions restrict lateral diffusion of lipids and membrane proteins, and thereby physically define the border between the apical and basolateral compartments of epithelial cells. Keen T.J.; Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases. Kalnine N., Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. The MGC Project Team; Genome Res. 14:2121-2127(2004).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of Claudin 7 only when phosphorylated at tyrosine 210.
Subcellular Location	Cell membrane, Multi-pass membrane protein, Basolateral cell membrane, Cell junction, tight junction

Uniprot	O95471
Database Links	HGNC:2049 OMIM:609131 KEGG:hsa:1366 STRING:9606.ENSP00000353475 UniGene:Hs.513915
Function	Plays a major role in tight junction-specific obliteration of the intercellular space.
Protein Families	Claudin family
Tissue Specificity	Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (L

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560225	CSB-PA729723	100ul	$360		Add to Cart

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