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Home / Primary Antibodies

Phospho-CEBPA (Thr230) Antibody

SKU : BHA10560220

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA599746
Alternative Names	CCAAT/enhancer-binding protein alpha C/EBP alpha CEBPA;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells.Xanthopoulos K.G. Biochem. Biophys. Res. Commun. 215:106-113(1995)Schalwijk J. Biol. Chem. Hoppe-Seyler 378:373-379(1997)SeattleSNPs variation discovery resource Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of threonine 230 (P-P-T(p)-P-V) derived from Human C/EBP-α.
Involvement In Disease	Leukemia, acute myelogenous (AML)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells.Xanthopoulos K.G. Biochem. Biophys. Res. Commun. 215:106-113(1995)Schalwijk J. Biol. Chem. Hoppe-Seyler 378:373-379(1997)SeattleSNPs variation discovery resource Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Species	Homo Sapiens (Human)
Specificity	The Antibody detects endogenous levels of C/EBP-α only when phosphorylated at Thr230.
Subcellular Location	Nucleus, SUBCELLULAR LOCATION: Isoform 4: Nucleus, nucleolus

Uniprot	P49715
Database Links	HGNC:1833 OMIM:116897 KEGG:hsa:1050 STRING:9606.ENSP00000427514 UniGene:Hs.76171
Function	Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta. Binds directly to the consensus DNA sequence 5'-T[TG]NNGNAA[TG]-3' acting as an activator on distinct target genes
Protein Families	BZIP family, C/EBP subfamily

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560220	CSB-PA599746	100ul	$360		Add to Cart

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