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Home / Primary Antibodies

Phospho-CDKN1B (Thr198) Antibody

SKU : BHA10560039

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA936236
Alternative Names	KIP1, MEN4, CDKN4, MEN1B, P27KIP1
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of Threonine 198(R-R-R(p)-Q-T) derived from Human p27 Kip1.
Involvement In Disease	Multiple endocrine neoplasia 4 (MEN4)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of p27 Kip1 only when phosphorylated at Threonine 198.
Subcellular Location	Nucleus, Cytoplasm, Endosome

Uniprot	P46527
Database Links	HGNC:1785 OMIM:600778 KEGG:hsa:1027 STRING:9606.ENSP00000228872 UniGene:Hs.238990
Function	Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA
Pathway	ErbB signaling pathway HIF-1 signaling pathway PI3K-Akt signaling pathway Cell cycle AGE-RAGE signaling pathway in diabetic complications FoxO signaling pathway
Protein Families	CDI family
Tissue Specificity	Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney.

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560039	CSB-PA936236	100ul	$360		Add to Cart

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