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Home / Antibodies

Phospho-CBX3 (Ser93) Antibody

SKU : BHA10560206

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA910579
Alternative Names	HECH; HP1 gamma; HP1Hs-gamma; chromobox 3;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.Ye Q., J. Biol. Chem. 271:14653-14656(1996).Ye Q., Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.Koike N., FEBS Lett. 467:17-21(2000)
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of Serine 93(R-L-S(p)-L-S) derived from Human HP1γ .
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.Ye Q., J. Biol. Chem. 271:14653-14656(1996).Ye Q., Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.Koike N., FEBS Lett. 467:17-21(2000)
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of HP1γ only when phosphorylated at serine 93.
Subcellular Location	Nucleus

Uniprot	Q13185
Database Links	HGNC:1553 OMIM:604477 KEGG:hsa:11335 STRING:9606.ENSP00000336687 UniGene:Hs.381189
Function	Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitement of NIPBL to sites of DNA damage at double-strand breaks (DSBs)

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560206	CSB-PA910579	100ul	$360		Add to Cart

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