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Home / Primary Antibodies

Phospho-CAV2 (Tyr27) Antibody

SKU : BHA10560212

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA946051
Alternative Names	CAV2; Caveolin-2;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Two transcript variants encoding distinct isoforms have been identified for this gene. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by one transcript.Scherer P.E., Proc. Natl. Acad. Sci. U.S.A. 93:131-135(1996).Scherer P.E., J. Biol. Chem. 272:29337-29346(1997).Engelman J.A., FEBS Lett. 448:221-230(1999).
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of tyrosine 27 (L-E-Y(p)-A-D) derived from Human Caveolin 2.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Two transcript variants encoding distinct isoforms have been identified for this gene. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by one transcript. Scherer P.E., Proc. Natl. Acad. Sci. U.S.A. 93:131-135(1996). Scherer P.E., J. Biol. Chem. 272:29337-29346(1997). Engelman J.A., FEBS Lett. 448:221-230(1999).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of Caveolin 2 only when phosphorylated at tyrosine 27.
Subcellular Location	Nucleus, Cytoplasm, Golgi apparatus membrane, Peripheral membrane protein, Cell membrane, Peripheral membrane protein, Membrane, caveola, Peripheral membrane protein

Uniprot	P51636
Database Links	HGNC:1528 OMIM:601048 KEGG:hsa:858 STRING:9606.ENSP00000222693 UniGene:Hs.212332
Function	May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).
Pathway	Focal adhesion Endocytosis
Protein Families	Caveolin family
Tissue Specificity	Expressed in endothelial cells, smooth muscle cells, skeletal myoblasts and fibroblasts.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560212	CSB-PA946051	100ul	$360		Add to Cart

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