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Home / Primary Antibodies / IHC Antibodies

Phospho-CASP9 (Thr125) Antibody

SKU : BHA10560442

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA938158
Alternative Names	APAF-3; MCH6; RNCASP9; CASP-9; ICE-LAP6
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.Duan H., J. Biol. Chem. 271:16720-16724(1996).Srinivasula S.M., J. Biol. Chem. 271:27099-27106(1996).Hadano S., Mamm. Genome 10:757-760(1999)
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of threonine 125 (P-E-T(p)-P-R) derived from Human Caspase 9.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9. Duan H., J. Biol. Chem. 271:16720-16724(1996). Srinivasula S.M., J. Biol. Chem. 271:27099-27106(1996). Hadano S., Mamm. Genome 10:757-760(1999)
Species	Homo Sapiens (Human)
Specificity	The antiserum was produced against synthesized phosphopeptide derived from human Caspase 9 around the phosphorylation site of threonine 125 (P-E-TP-P-R).

Uniprot	P55211
Database Links	HGNC:1511 OMIM:602234 KEGG:hsa:842 STRING:9606.ENSP00000330237 UniGene:Hs.329502
Function	Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).; FUNCTION
Pathway	p53 signaling pathway PI3K-Akt signaling pathway VEGF signaling pathway Apoptosis
Protein Families	Peptidase C14A family
Tissue Specificity	Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:1000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560442	CSB-PA938158	100ul	$360		Add to Cart

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