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Home / Antibodies

Phospho-CAMK2A (Thr286) Antibody

SKU : BHA10560397

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA293488
Alternative Names	CAMKA
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity Pak JH, et al. Proc Natl Acad Sci U S A. 2000 Oct 10; 97(21): 11232-11237 Hudmon A, et al. J Cell Biol. Author manuscript; available in PMC 2006 May 7 Miller P, et al. PLoS Biol. 2005 Apr; 3(4): e107 Runyan JD, et al. Learn Mem. 2005 Mar; 12(2): 103-110.
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of threonine 286 (Q-E-T(p)-V-D) derived from Human CaMKII.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity Pak JH, et al. Proc Natl Acad Sci U S A. 2000 Oct 10; 97(21): 11232-11237 Hudmon A, et al. J Cell Biol. Author manuscript; available in PMC 2006 May 7 Miller P, et al. PLoS Biol. 2005 Apr; 3(4): e107 Runyan JD, et al. Learn Mem. 2005 Mar; 12(2): 103-110.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of CaMKII only when phosphorylated at threonine 286.
Subcellular Location	Cell junction, synapse, presynaptic cell membrane, Cell junction, synapse

Uniprot	Q9UQM7
Database Links	HGNC:1460 OMIM:114078 KEGG:hsa:815 STRING:9606.ENSP00000381412 UniGene:Hs.743976
Function	CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity). Phosphorylates transcription factor FOXO3 on 'Ser-298'
Pathway	Calcium signaling pathway cAMP signaling pathway ErbB signaling pathway HIF-1 signaling pathway Melanogenesis Wnt signaling pathway Necroptosis Glucagon signaling pathway Neurotrophin signaling pathway
Protein Families	Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560397	CSB-PA293488	100ul	$360		Add to Cart

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