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Home / Antibodies

Phospho-ATXN1 (Ser776) Antibody

SKU : BHA10560027

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA597893
Alternative Names	ATX1, D6S504E, SCA1
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function.
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of Serine 776(R-W-S(p)-A-P) derived from Human Ataxin 1.
Involvement In Disease	Spinocerebellar ataxia 1 (SCA1)
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of Ataxin 1 only when phosphorylated at Serine 776.
Subcellular Location	Cytoplasm, Nucleus

Uniprot	P54253
Gene Id	6310
Database Links	HGNC:10548 OMIM:164400 KEGG:hsa:6310 STRING:9606.ENSP00000244769 UniGene:Hs.434961
Function	Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism
Protein Families	ATXN1 family
Tissue Specificity	Widely expressed throughout the body.
Weight	86,923 Da

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560027	CSB-PA597893	100ul	$360		Add to Cart

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