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Home / Antibodies

Phospho-ATF4 (Ser219) Antibody

SKU : BHA10560249

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA172388
Alternative Names	ATF4; CREB-2; DNA-binding protein TAXREB67; TXREB;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	ATF4 encodes a transcription factor that was originally identified as a widely expressed mammalian DNA bindingprotein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication.Sato T., Shimotohno K. J. Virol. 65:1420-1426(1991)Leiden J.M. Proc. Natl. Acad. Sci. U.S.A. 89:4820-4824(1992)Bridgeman A.M. Wright H. Nature 402:489-495(1999)
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of Serine 219 (N-D-S(p)-G-T) derived from Human ATF-4.
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	ATF4 encodes a transcription factor that was originally identified as a widely expressed mammalian DNA bindingprotein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication. Sato T., Shimotohno K. J. Virol. 65:1420-1426(1991) Leiden J.M. Proc. Natl. Acad. Sci. U.S.A. 89:4820-4824(1992) Bridgeman A.M. Wright H. Nature 402:489-495(1999)
Species	Homo Sapiens (Human)
Specificity	The Antibody detects endogenous levels of ATF-4 only when phosphorylated at Serine 219.
Subcellular Location	Cytoplasm, Cell membrane, Nucleus, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome

Uniprot	P18848
Gene Id	468
Database Links	HGNC:786 OMIM:604064 KEGG:hsa:468 STRING:9606.ENSP00000336790 UniGene:Hs.496487
Function	Transcriptional activator. Binds the cAMP response element (CRE) (consensus
Pathway	Estrogen signaling pathway MAPK signaling pathway PI3K-Akt signaling pathway TNF signaling pathway Apoptosis MAPK Erk pathway Protein processing in endoplasmic reticulum Th17 cell differentiation Thyroid hormone synthesis cGMP-PKG signaling pathway ER Stress pathway Glucagon signaling pathway Neurotrophin signaling pathway
Protein Families	BZIP family
Weight	38,590 Da

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560249	CSB-PA172388	100ul	$360		Add to Cart

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