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Home / Primary Antibodies

Phospho-ATF1 (Ser63) Antibody

SKU : BHA10560084

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA107926
Alternative Names	ATF1; Activating transcription factor 1; Cyclic-AMP-dependent transcription factor ATF-1; TCR-ATF1; TREB36 protein
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation. Mackenzie KF, et al. (2013) J Immunol 190, 565-77 Dickinson RJ, et al. (2011) J Biol Chem 286, 38018-26 Wang J, Zhou JY, Wu GS (2011) J Biol Chem 286, 22384-92
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of serine 63(R-P-S(p)-Y-R) derived from Human ATF1 .
Involvement In Disease	Angiomatoid fibrous histiocytoma (AFH)
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation. Mackenzie KF, et al. (2013) J Immunol 190, 565-77 Dickinson RJ, et al. (2011) J Biol Chem 286, 38018-26 Wang J, Zhou JY, Wu GS (2011) J Biol Chem 286, 22384-92
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of ATF1 only when phosphorylated at serine 63.
Subcellular Location	Nucleus

Uniprot	P18846
Gene Id	466
Database Links	HGNC:783 OMIM:123803 KEGG:hsa:466 STRING:9606.ENSP00000262053 UniGene:Hs.648565
Function	This protein binds the cAMP response element (CRE) (consensus
Protein Families	BZIP family, ATF subfamily
Weight	15,295 Da

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560084	CSB-PA107926	100ul	$360		Add to Cart

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