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Home / Antibodies

Phospho-ADRB2 (Ser346) Antibody

SKU : BHA10560131

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA758017
Alternative Names	ADRB2R; B2AR; adrenergic receptor; beta-2;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.Gao S, Malbon C, Wang HY (2014) J Mol Signal 9, 3 24690384 Curated InfoVistein R, Puthenveedu MA (2013) Proc Natl Acad Sci U S A 110, 15289-94 Gimenez LE, et al. (2012) J Biol Chem 287, 9028-40
Host	Rabbit
Immunogen	Peptide sequence around phosphorylation site of serine 346 (R-S-S(p)-L-K) derived from Human Adrenergic Receptor beta2.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. Gao S, Malbon C, Wang HY (2014) J Mol Signal 9, 3 24690384 Curated Info Vistein R, Puthenveedu MA (2013) Proc Natl Acad Sci U S A 110, 15289-94 Gimenez LE, et al. (2012) J Biol Chem 287, 9028-40
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of Adrenergic Receptor beta2 only when phosphorylated at serine 346.
Subcellular Location	Cell membrane, Multi-pass membrane protein, Early endosome

Uniprot	P07550
Gene Id	154
Database Links	HGNC:286 OMIM:109690 KEGG:hsa:154 STRING:9606.ENSP00000305372 UniGene:Hs.2551
Function	Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
Pathway	Calcium signaling pathway cAMP signaling pathway cGMP-PKG signaling pathway
Protein Families	G-protein coupled receptor 1 family, Adrenergic receptor subfamily, ADRB2 sub-subfamily
Weight	46459

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Purity	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10560131	CSB-PA758017	100ul	$360		Add to Cart

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