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Home / Antibodies

Perforin Antibody / PRF1 (V3910SAF)

SKU : BHA17125724

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NSJ Bioreagents

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Mfr.No.	V3910SAF-100UG
Clonality	Monoclonal (mouse origin)
Description	Perforin is a pore-forming protein that leads to osmotic lysis of the target cells and subsequently enables granzymes to enter the target cells and activate apoptosis. Perforin has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. It is one of the main cytolytic proteins of cytolytic granules, and is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. The expression of perforin is reportedly upregulated in activated CD8+ T-cells, natural killer cells and some CD4+ T-cells.
Formulation	1 mg/ml in 1X PBS; BSA free, sodium azide free
Host	Mouse
Immunogen Region	A portion of amino acids 413-552 from the human protein was used as the immunogen for the Perforin antibody.
Isotype	Mouse IgG2b, kappa
Species Reactivity	Human
Note	Optimal dilution of the Perforin antibody should be determined by the researcher.

Uniprot	P14222

Format	Purified
Purity	Protein G affinity
Storage	Store the Perforin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Applications	ELISA
Description	ELISA (order BSA/sodium azide-free format for coating)

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17125724	V3910SAF-100UG	100 ug	$499		Add to Cart

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