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Home / Primary Antibodies

PECAM1 Antibody

SKU : BHA10557543

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA616412
Alternative Names	CD31; PECAM-1; FLJ34100; FLJ58394; PECAM1
Categories	Primary Antibodies
Clonality	polyclonal
Description	Induces susceptibility to atherosclerosis By similarity. Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC). Brown S., Heinisch I., Ross E., Shaw K., Buckley C.D., Savill J.Nature 418:200-203(2002) Bergom C., Paddock C., Gao C., Holyst T., Cell Sci. 121:1235-1242(2008) Dasgupta B., Dufour E., Mamdouh Z., Muller W.A. J. Immunol. 182:5041-5051(2009)
Host	Rabbit
Immunogen	Peptide sequence around aa.730~734(R-T-E-G-S) derived from Human CD31(PECAM1).
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Induces susceptibility to atherosclerosis By similarity. Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC). Brown S., Heinisch I., Ross E., Shaw K., Buckley C.D., Savill J.Nature 418:200-203(2002) Bergom C., Paddock C., Gao C., Holyst T., Cell Sci. 121:1235-1242(2008) Dasgupta B., Dufour E., Mamdouh Z., Muller W.A. J. Immunol. 182:5041-5051(2009)
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of total CD31 protein.
Subcellular Location	Cell membrane, Single-pass type I membrane protein, Note=Cell surface expression on neutrophils is down-regulated upon fMLP or CXCL8/IL8-mediated stimulation, SUBCELLULAR LOCATION: Isoform Long: Cell membrane, Single-pass type I membrane protein, Membrane raft, Cell junction, Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells, SUBCELLULAR LOCATION: Isoform Delta15: Cell junction

Uniprot	P16284
Database Links	HGNC:8823 OMIM:173445 KEGG:hsa:5175 UniGene:Hs.376675
Function	Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions
Pathway	Leukocyte transendothelial migration
Tissue Specificity	Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells (PubMed:18388311, PubMed:21464369). Expressed in human umbilical vein endothelial cells (HUVECs) (at protein level) (PubMed:19342684, PubMed:17580

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557543	CSB-PA616412	100ul	$297		Add to Cart

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