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Home / Primary Antibodies

PDK1 Antibody

SKU : BHA10558608

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA296362
Alternative Names	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1; mitochondrial; mitochondrial pyruvate dehydrogenase; lipoamide; kinase isoenzyme 1
Categories	Primary Antibodies
Clonality	polyclonal
Description	Serine/threonine kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.Gudi R., J. Biol. Chem. 270:28989-28994(1995).Ota T., Nat. Genet. 36:40-45(2004).Burkard T.R., BMC Syst. Biol. 5:17-17(2011).
Host	Rabbit
Immunogen	Synthesized peptide derived from Internal of Human PDK1.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Serine/threonine kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress. Gudi R., J. Biol. Chem. 270:28989-28994(1995). Ota T., Nat. Genet. 36:40-45(2004). Burkard T.R., BMC Syst. Biol. 5:17-17(2011).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total PDK1 protein.
Subcellular Location	Mitochondrion matrix

Uniprot	Q15118
Database Links	HGNC:8809 OMIM:602524 KEGG:hsa:5163 STRING:9606.ENSP00000282077 UniGene:Hs.470633
Function	Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.
Pathway	HIF-1 signaling pathway Nitric oxide signaling
Protein Families	PDK/BCKDK protein kinase family
Tissue Specificity	Expressed predominantly in the heart. Detected at lower levels in liver, skeletal muscle and pancreas.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558608	CSB-PA296362	100ul	$297		Add to Cart

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