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Home / Primary Antibodies

PDGFB Antibody

SKU : BHA10557733

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA153276
Alternative Names	PDGF2; ONCOGENE SIS; PDGF B CHAIN; PLATELET-DERIVED GROWTH FACTOR B CHAIN; SIMIAN SARCOMA VIRAL ONCOGENE HOMOLOG
Categories	Primary Antibodies
Clonality	polyclonal
Description	Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA By similarity.Li Fang, Arterioscler. Thromb. Vasc. Biol., Apr 2004; 24: 787 - 792. EJ Battegay, J. Cell Biol., May 1994; 125: 917. RA Seifert, J. Biol. Chem., Feb 1993; 268: 4473 - 4480. Jason Liu, Am J Physiol Lung Cell Mol Physiol, May 1998; 274: 702.
Host	Rabbit
Immunogen	Synthesized peptide derived from Human PDGFB.
Involvement In Disease	Basal ganglia calcification, idiopathic, 5 (IBGC5)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA By similarity. Li Fang, Arterioscler. Thromb. Vasc. Biol., Apr 2004; 24: 787 - 792. EJ Battegay, J. Cell Biol., May 1994; 125: 917. RA Seifert, J. Biol. Chem., Feb 1993; 268: 4473 - 4480. Jason Liu, Am J Physiol Lung Cell Mol Physiol, May 1998; 274: 702.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total PDGFB protein.
Subcellular Location	Secreted

Uniprot	P01127
Database Links	HGNC:8800 OMIM:190040 KEGG:hsa:5155 STRING:9606.ENSP00000330382 UniGene:Hs.1976
Function	Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin
Pathway	Jak-STAT signaling pathway MAPK signaling pathway PI3K-Akt signaling pathway Focal adhesion Gap junction Regulation of actin cytoskeleton Ras signaling pathway Phospholipase D signaling pathway Rap1 signaling pathway
Protein Families	PDGF/VEGF growth factor family
Tissue Specificity	Expressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney. Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and lung.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557733	CSB-PA153276	100ul	$297		Add to Cart

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