PD-L1 is a checkpoint regulator in immune cells, it is expressed on immune or non-hematopoietic cells. Expression of the protein is seen during pregnancy where it has a role in suppressing the immune system. PD-L1 induces an inhibitory signal in activated T-cells and promotes T-cell apoptosis. It is overexpressed in a number of different cancers where it is believed to play a significant role in the cancer s ability to evade the immune system.
Formulation
500 ul at 0.1 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Host
Mouse
Immunogen Region
A portion of amino acids 39-191 from the human protein was used as the immunogen for this PD-L1 antibody.
Isotype
Mouse IgG2b, kappa
Species Reactivity
Human, Mouse
Note
Optimal dilution of the PD-L1 antibody should be determined by the researcher.
Uniprot
Q9NZQ7
Format
PE Conjugate
Purity
Protein G affinity chromatography
Storage
Store the PD-L1 antibody at 2-8oC, protected from light.
Applications
FACS, IF
Description
Flow cytometry: 1-2ug/million cells in 0.1ml,Immunofluorescence: 1-2ug/ml