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Home / Primary Antibodies

PARP2 Antibody

SKU : BHA10558405

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA152331
Alternative Names	Poly [ADP-ribose] polymerase 2; PARP-2; NAD(+) ADP-ribosyltransferase 2; Poly[ADP-ribose] synthetase 2; pADPRT-2
Categories	Primary Antibodies
Clonality	polyclonal
Description	Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.Sugano S., Nat. Genet. 36:40-45(2004).de Murcia G.M., J. Biol. Chem. 277:23028-23036(2002).Bennett K.L., Submitted (OCT-2008).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human PARP2.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Sugano S., Nat. Genet. 36:40-45(2004). de Murcia G.M., J. Biol. Chem. 277:23028-23036(2002). Bennett K.L., Submitted (OCT-2008).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total PARP2 protein.
Subcellular Location	Nucleus

Uniprot	Q9UGN5
Database Links	HGNC:272 OMIM:607725 KEGG:hsa:10038 STRING:9606.ENSP00000250416 UniGene:Hs.409412
Function	Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism
Pathway	Apoptosis Necroptosis
Tissue Specificity	Widely expressed, mainly in actively dividing tissues. The highest levels are in the brain, heart, pancreas, skeletal muscle and testis; also detected in kidney, liver, lung, placenta, ovary and spleen; levels are low in leukocytes, colon, small intestine

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558405	CSB-PA152331	100ul	$297		Add to Cart

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