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Home / Antibodies

PARD3 Antibody

SKU : BHA10559345

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA921456
Alternative Names	Partitioning-defective 3 homolog; PARD-3; PAR-3; Atypical PKC isotype-specific-interacting protein; ASIP
Categories	Primary Antibodies
Clonality	polyclonal
Description	Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions By similarity. Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons.Joberty G., Nat. Cell Biol. 2:531-539(2000).Fang C.M., Cell Res. 11:223-229(2001).Kohjima M., Biochem. Biophys. Res. Commun. 299:641-646(2002).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human PARD3.
Involvement In Disease	Neural tube defects (NTD)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions By similarity. Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons. Joberty G., Nat. Cell Biol. 2:531-539(2000). Fang C.M., Cell Res. 11:223-229(2001). Kohjima M., Biochem. Biophys. Res. Commun. 299:641-646(2002).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total PARD3 protein.
Subcellular Location	Cytoplasm, Endomembrane system, Cell junction, Cell junction, tight junction, Cell junction, adherens junction, Cell membrane, Cytoplasm, cell cortex, Cytoplasm, cytoskeleton

Uniprot	Q8TEW0
Database Links	HGNC:16051 OMIM:182940 KEGG:hsa:56288 STRING:9606.ENSP00000363921 UniGene:Hs.131489
Function	Adapter protein involved in asymmetrical cell division and cell polarization processes
Pathway	Chemokine signaling pathway Hippo signaling pathway Adherens junction Rap1 signaling pathway Endocytosis
Protein Families	PAR3 family
Tissue Specificity	Widely expressed.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IF

Description

ELISA ; WB ; IF, WB ; ELISA ; IF

Dilution

WB	1:500-1:3000
IF	1:100-1:500

Tested Application

ELISA,WB,IF;WB:1:500-1:3000,IF:1:100-1:500

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559345	CSB-PA921456	100ul	$297		Add to Cart

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