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Home / Antibodies

PAPP-A Antibody / Pappalysin-1 (V7549SAF)

SKU : BHA17126673

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NSJ Bioreagents

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Mfr.No.	V7549SAF-100UG
Clonality	Monoclonal (mouse origin)
Description	The PAPPA gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. (RefSeq)
Formulation	1 mg/ml in 1X PBS; BSA free, sodium azide free
Host	Mouse
Immunogen Region	A portion of amino acids 351-523 from the human protein was used as the immunogen for the PAPPA antibody.
Isotype	Mouse IgG2b, kappa
Species Reactivity	Human
Note	The stated application concentrations are suggested starting points. Titration of the PAPPA antibody may be required due to differences in protocols and secondary/substrate sensitivity.1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Uniprot	Q13219

Format	Purified
Purity	Protein G affinity chromatography
Storage	Store the PAPPA antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Applications	IHC-P
Description	Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT,Prediluted IHC only format: incubate for 30 min at RT (1)

Product Manual	<a href="https://www.nsjbio.com/tds-pdf/pappa-antibody-idip-1-v7549" target="_blank">Datasheet</a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA17126673	V7549SAF-100UG	100 ug	$499		Add to Cart

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