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Home / Antibodies

p53 Antibody / TP53 (N-Terminal Region) (V2282)

SKU : BHA17111602

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NSJ Bioreagents

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Mfr.No.	V2282, V2282-20UG, V2282-100UG
Antigen	p53
Clonality	Monoclonal
Description	This antibody is specific for a 53kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53 under denaturing and non-denaturing conditions. The antibody epitope maps within the N-terminus (aa 20-25) of p53 oncoprotein. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. antibody to p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
Formulation	0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Host	Mouse
Immunogen Region	Recombinant human wild-type p53 protein was used as the immunogen for this antibody.
Isotype	IgG2a,kappa
Predicted Reactivity	Human
Reactivity	Human
Recombinant	No
Subcellular Location	Nuclear

Gene Id	7157
Clone No	BP53-12

Concentration	0.2 mg/ml
Format	Purified
Purification	Protein G affinity chromatography
Storage	Store the p53 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Applications	WB, IHC-P
Dilution	Western blot: 1-2ug/ml,Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT

Product Manual	Data Sheet

No Description Available.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA17111602-1	V2282-20UG	20ug	$219		Add to Cart
BHA17111602-2	V2282-100UG	100ug	$499		Add to Cart

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