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Home / Antibodies

p53 Antibody / TP53 (C-Terminal Region) (V3510SAF)

SKU : BHA17125159

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NSJ Bioreagents

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Mfr.No.	V3510SAF-100UG
Clonality	Monoclonal (mouse origin)
Description	This antibody is specific to a conserved determinant of the p53 protein. PAb 122 binds to the C-terminus (aa 370-378) of both wild type and mutated p53. When microinjected into nuclei, PAb 122 blocked re-entry into the S-phase of the cell cycle. Mutation and/or allelic loss of p53 is one of the causes of a variety of mesenchymal and epithelial tumors. If it occurs in the germ line, such tumors run in families. p53 binds to a DNA consensus sequence, the p53 response element, and it regulates normal cell growth cycle events by activating transcription of genes, involved either in progression through the cycle, or causing arrest in G1 when the genome is damaged. In most transformed and tumor cells the concentration of p53 is increased 5-1000 fold over the minute concentrations (1000 molecules cell) in normal cells, principally due to the increased half-life (4 h) compared to that of the wild-type (20 min). The protein in the nucleus, but is detectable at the plasma membrane during mitosis and when certain mutations modulate cytoplasmic/nuclear distribution. Its the most commonly mutated gene in spontaneously occurring human cancers. Mutations arise with an average frequency of 70% but incidence varies from zero in carcinoid lung tumors to 97% in primary melanomas. High concentrations of p53 protein are transiently expressed in human epidermis and superficial dermal fibroblasts following mild ultraviolet irradiation.
Formulation	1 mg/ml in 1X PBS; BSA free, sodium azide free
Host	Mouse
Immunogen Region	SV40-transformed mouse B4 cells were used as the immunogen for this antibody. Its epitope maps near the C-terminal end (aa 370-378) of p53.
Isotype	Mouse IgG2b, kappa
Species Reactivity	Human, Mouse, Rat
Note	Variations in protocols, secondaries and substrates may require the p53 antibody to be titered up or down for optimal performance.

Format	Purified
Purity	Protein G affinity chromatography
Storage	Store the p53 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Applications	ELISA
Description	ELISA (order BSA/sodium azide-free format for coating)

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17125159	V3510SAF-100UG	100 ug	$499		Add to Cart

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