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Home / Primary Antibodies

p53 Antibody (phospho-S315) (F48432)

SKU : BHA17101221

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NSJ Bioreagents

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Mfr.No.	F48432, F48432-0.08ML, F48432-0.4ML
Antigen	Phospho-p53
Clonality	Polyclonal
Description	Tumor protein p53, a nuclear protein, plays an essential role in the regulation of cell cycle, specifically in the transition from G0 to G1. It is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing DNA-binding, oligomerization and transcription activation domains. It is postulated to bind as a tetramer to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of the TP53 gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome.
Formulation	In 1X PBS, pH 7.4, with 0.09% sodium azide
Host	Rabbit
Immunogen Region	This phospho-p53 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS315 of human p53.
Isotype	Ig
Predicted Reactivity	Human
Reactivity	Human
Recombinant	No

Uniprot	P04637

Format	Antigen affinity purified
Purification	Antigen affinity
Storage	Aliquot the phospho-p53 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Applications	DB, IHC, ELISA
Dilution	Dot blot: 1:500,IHC (Paraffin): 1:50-1:100

Product Manual	Data Sheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA17101221-1	F48432-0.08ML	0.08ml	$165		Add to Cart
BHA17101221-2	F48432-0.4ML	0.4ml	$379		Add to Cart

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